Ikonomovic MD, Mufson EJ, Wuu J, Cochran EJ, Bennett DA, Dekosky ST.
Cholinergic plasticity in hippocampus of individuals with mild cognitive impairment: correlation with Alzheimer's neuropathology.
J Alzheimers Dis. 2003 Feb;5(1):39-48.
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As a clinician, I would suggest for early intervention with AChE inhibitors in MCI stage to prolong the compensatory process before clinical manifestation of AD.
I have a question: is there a relationship of increased mio-inositol and cholinergic activity in MCI? If so, could MI be a marker of MCI which will be develop to AD? How do we explain this phenomena? Thank you.