Davis KL, Mohs RC, Marin D, Purohit DP, Perl DP, Lantz M, Austin G, Haroutunian V.
Cholinergic markers in elderly patients with early signs of Alzheimer disease.
JAMA. 1999 Apr 21;281(15):1401-6.
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This study examined the cholinergic system in postmortem brain samples of patients with CDR 0.0 to 2.0 in comparison to 4.0 - 5.0. The abstract states: 'cholinergic deficits were not apparent in individuals with mild AD and were not present until relatively late in the course of the disease.' The authors suggest that this makes a case for cholinergic therapy in late stage, rather than early stage AD.