Simons M, Keller P, De Strooper B, Beyreuther K, Dotti CG, Simons K.
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons.
Proc Natl Acad Sci U S A. 1998 May 26;95(11):6460-4.
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This is an interesting paper as it may explain the role of ApoE in Ab production as well as the mechanism of g-secretase cleavage. The problem is that no correlation has been demonstrated between cholesterol levels and AD.
This paper shows that cholesterol is a key for APP metabolism to produce A-beta. This may be relevant to the function of ApoE.
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