. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc Natl Acad Sci U S A. 1998 May 26;95(11):6460-4. PubMed.


Please login to recommend the paper.


  1. This is an interesting paper as it may explain the role of ApoE in Ab production as well as the mechanism of g-secretase cleavage. The problem is that no correlation has been demonstrated between cholesterol levels and AD.

  2. This paper shows that cholesterol is a key for APP metabolism to produce A-beta. This may be relevant to the function of ApoE.

Make a Comment

To make a comment you must login or register.