. Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects. Ann Neurol. 2009 Apr;65(4):403-13. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)
Cohort
(N)
Measurement
Mean ± SD
Method;
Assay Name;
Manufacturer
Diagnostic
Criteria
Aβ1-42
(CSF)
AD
(100)
144 ± 41
pg/mL
xMAP;
AlzBio3;
Innogenetics
McKhann et al., 1984
Aβ1-42
(CSF)
CTRL-
CNC
(114)
206 ± 55
pg/mL
xMAP;
AlzBio3;
Innogenetics
tau-p181
(CSF)
AD
(100)
42 ± 20
pg/mL
xMAP;
AlzBio3;
Innogenetics
McKhann et al., 1984
tau-p181
(CSF)
CTRL-
CNC
(114)
25 ± 15
pg/mL
xMAP;
AlzBio3;
Innogenetics
tau-total
(CSF)
AD
(100)
122 ± 58
pg/mL
xMAP;
AlzBio3;
Innogenetics
McKhann et al., 1984
tau-total
(CSF)
CTRL-
CNC
(114)
70 ± 30
pg/mL
xMAP;
AlzBio3;
Innogenetics

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  1. I wonder whether the segregation power of this assay would be further strengthened if a marker of gliosis (GFAP, Iba1) or neuronal cell lysis (neurofilament) were added to the set.

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