Spies PE, Melis RJ, Sjögren MJ, Rikkert MG, Verbeek MM. Cerebrospinal fluid alpha-synuclein does not discriminate between dementia disorders. J Alzheimers Dis. 2009;16(2):363-9. PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : α-synuclein (CSF)
- CTRL vs AD : α-synuclein (CSF)
- DLB vs AD : α-synuclein (CSF)
- FTD vs AD : α-synuclein (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| α-synuclein (CSF) |
AD (131) |
37 ± 36.1 ng/mL |
ELISA; Other/Not Specified; In-house |
McKhann et al., 1984 |
| α-synuclein (CSF) |
CTRL- CNC (57) |
30.4 ± 19.1 ng/mL |
ELISA; Other/Not Specified; In-house |
|
| α-synuclein (CSF) |
DLB (40) |
38 ± 29 ng/mL |
ELISA; Other/Not Specified; In-house |
McKeith et al., 1996 |
| α-synuclein (CSF) |
FTD (39) |
49.1 ± 41.5 ng/mL |
ELISA; Other/Not Specified; In-house |
Neary et al., 1998 |
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