. Carbon 11-labeled pittsburgh compound B positron emission tomographic amyloid imaging in patients with APP locus duplication. Arch Neurol. 2008 Apr;65(4):540-4. PubMed.

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  1. This is the first paper to show (11)C-PiB binding in PET in hereditary cerebral amyloid angiopathy and APP locus duplication. The paper reports increased uptake of (11)C-PiB in the striatum and the posterior cingulate in two cases with APP duplication, while there was only a marginal increase in cortical regions. The finding suggests that PIB-PET may be useful in investigating subjects with suspected CAA.