Ostergaard L, Aamand R, Gutiérrez-Jiménez E, Ho YC, Blicher JU, Madsen SM, Nagenthiraja K, Dalby RB, Drasbek KR, Møller A, Braendgaard H, Mouridsen K, Jespersen SN, Jensen MS, West MJ.
The capillary dysfunction hypothesis of Alzheimer's disease.
Neurobiol Aging. 2013 Apr;34(4):1018-31.
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A fascinating paper describing how capillary dysfunction would be expected to initially lead to increased cerebral blood flow, followed by a transition to decreased blood flow as Alzheimer's disease progresses. The paper includes extensive and fascinating discussion of how many diverse observations fit into the authors' model.