Jicha GA, Weaver C, Lane E, Vianna C, Kress Y, Rockwood J, Davies P.
cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease.
J Neurosci. 1999 Sep 1;19(17):7486-94.
PubMed.
The authors generated "highly specific monoclonal antibodies, CP-3 and PG-5, which recognize the PKA-dependent phosphorylations of ser214 and ser409 in tau respectively. - - - neither site appears to be phosphorylated to any appreciable extent in normal rodent or human brain." These findings suggests reconsideration of earlier data from others indicating a high degree of tau phosphorylation in normal human brain.
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Banner Research Institute
The authors generated "highly specific monoclonal antibodies, CP-3 and PG-5, which recognize the PKA-dependent phosphorylations of ser214 and ser409 in tau respectively. - - - neither site appears to be phosphorylated to any appreciable extent in normal rodent or human brain." These findings suggests reconsideration of earlier data from others indicating a high degree of tau phosphorylation in normal human brain.
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