Calcium dyshomeostasis in white matter pathology.
Cell Calcium. 2010 Feb;47(2):150-7.
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Dysregulation of neuronal calcium homeostasis has long been recognized as an early event in neurodegenerative processes including those associated with Alzheimer disease. Elucidating the impact of calcium dyshomeostasis in the cells responsible for conductivity of signaling in the nervous system, e.g. oligodendrocytes, is likely to greatly expand our understanding of the mechanisms underlying the earliest deficits in electrophysiological signaling in brain characteristic of AD.
The extensive and critical roles calcium signaling has across several CNS and PNS cell types are difficult to grasp. This review does a good job of presenting an array of disease states that result from calcium dysregulation in a variety of cells other than neurons.
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