Lee JM, Blennow K, Andreasen N, Laterza O, Modur V, Olander J, Gao F, Ohlendorf M, Ladenson JH. The brain injury biomarker VLP-1 is increased in the cerebrospinal fluid of Alzheimer disease patients. Clin Chem. 2008 Oct;54(10):1617-23. Epub 2008 Aug 14 PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : Aβ42 (CSF)
- CTRL vs AD : Aβ42 (CSF)
- AD vs CTRL : VLP-1 (CSF)
- CTRL vs AD : VLP-1 (CSF)
- AD vs CTRL : tau-p181 (CSF)
- CTRL vs AD : tau-p181 (CSF)
- AD vs CTRL : tau-total (CSF)
- CTRL vs AD : tau-total (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| Aβ42 (CSF) |
AD (33) |
471 ± 172 ng/mL § |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| Aβ42 (CSF) |
CTRL- CNC (24) |
698 ± 230 ng/mL § |
ELISA; Innotest; Innogenetics |
|
| VLP-1 (CSF) |
AD (33) |
387 ± 157 pg/mL § |
ELISA; Other/Not Specified; In-house |
McKhann et al., 1984 |
| VLP-1 (CSF) |
CTRL- CNC (24) |
234 ± 101 pg/mL § |
ELISA; Other/Not Specified; In-house |
|
| tau-p181 (CSF) |
AD (33) |
100 ± 40 ng/mL § |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| tau-p181 (CSF) |
CTRL- CNC (24) |
61 ± 29 ng/mL § |
ELISA; Innotest; Innogenetics |
|
| tau-total (CSF) |
AD (33) |
735 ± 443 ng/mL § |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| tau-total (CSF) |
CTRL- CNC (24) |
395 ± 204 ng/mL § |
ELISA; Innotest; Innogenetics |
§ Data supplied to Alzforum by author
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