Rinne JO, Suotunen T, Rummukainen J, Alafuzoff I, Savolainen S, Helin S, Seppala T, Herukka S-, Koivisto A, Leinonen V.
Brain [11C]-PiB uptake reflects beta-amyloid burden detected by immunohistochemistry in frontal cortex biopsy specimens.
Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
Objective: To compare Carbon 11.labeled Pittsburgh Compound B ([11C]PiB) positron emission tomography
(PET) findings in patients with and without Alzheimer's disease lesions in frontal cortical biopsy specimens.
Patients: 21 patients (14 women, 14 men; mean age; SD 72.7; 4.6 years, range 62.83 years) who had undergone
intraventricular pressure monitoring with a right frontal cortical biopsy for suspected normal-pressure hydrocephalus
participated in the study.
Methods: A dynamic 90 min [11C]PiB PET scan was performed. The data was quantified as a region-tocerebellar
cortex ratio from 60-90 min after injection by using an automated region-of interest analysis. Ventricular
cerebrospinal fluid (CSF) As-, tau- and phophotau-levels were measured. The number of As aggregates in the
frontal cortical biopsy specimen was evaluated by immunohistochemistry.
Results: In patients with As aggregates in the frontal cortical biopsy specimen, PET imaging revealed significantly
higher [11C]PiB uptake in the right frontal cortex and in the composite neocortical score (an average of uptake in
frontal, parietal, lateral temporal, occipital and posterior cingulate cortices). There was a clear association between
the number of As aggregates in the frontal cortical biopsy specimen and both [11C]PiB uptake in the right frontal
cortex (r = 0.91, p Conclusions: Our study supports the use of noninvasive [11C]PiB PET in the assessment of As deposition in the
brain by showing a clear association between in vivo [11C]PiB uptake and the number of As aggregates in frontal
cortical biopsy specimen.