. Both total and phosphorylated tau are increased in Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2001 May;70(5):624-30. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)
Cohort
(N)
Measurement
Mean ± SD
Method;
Assay Name;
Manufacturer
Diagnostic
Criteria
albumin ratio
(CSF/Serum)
AD-
Possible Alzheimer's Disease
(19)
7.9 ± 2.9
mg/L:g/L
Nephelometry;
Other/Not Specified;
Not specified
McKhann et al., 1984
albumin ratio
(CSF/Serum)
AD-
Probable Alzheimer's Disease
(41)
5.4 ± 1.8
mg/L:g/L
Nephelometry;
Other/Not Specified;
Not specified
McKhann et al., 1984
albumin ratio
(CSF/Serum)
CTRL-
CNC
(17)
5.3 ± 1.8
mg/L:g/L
Nephelometry;
Other/Not Specified;
Not specified
tau-p181
(CSF)
AD-
Possible Alzheimer's Disease
(19)
18.01 ± 5.86
pM
ELISA;
Innotest;
Innogenetics
McKhann et al., 1984
tau-p181
(CSF)
AD-
Probable Alzheimer's Disease
(41)
23.1 ± 10.1
pM
ELISA;
Innotest;
Innogenetics
McKhann et al., 1984
tau-p181
(CSF)
CTRL-
CNC
(17)
15.9 ± 5.7
pM
ELISA;
Innotest;
Innogenetics
tau-total
(CSF)
AD-
Possible Alzheimer's Disease
(19)
16.34 ± 4.3
pM
ELISA;
Innotest;
Innogenetics
McKhann et al., 1984
tau-total
(CSF)
AD-
Probable Alzheimer's Disease
(41)
20 ± 7.6
pM
ELISA;
Innotest;
Innogenetics
McKhann et al., 1984
tau-total
(CSF)
CTRL-
CNC
(17)
8.3 ± 2.8
pM
ELISA;
Innotest;
Innogenetics

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