. Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain. J Biol Chem. 2002 May 3;277(18):16278-84. Epub 2002 Feb 14 PubMed.

Recommends

Please login to recommend the paper.

Comments

  1. Interesting study. A bit surprising since glu11 cleaved Ab is not that abundant in vitro or in vivo. Or, maybe we just haven't looked at the glu11 enough?

  2. This paper provides important information about BACE cleavage. It has been known for a long time that multiple Ab peptides consisting of X-38-42 are generated. This paper begins to look at the mechanism of generation of the X-38-42 peptides, and shows that the site of generation plays a role. This is interesting because it points to the importance of trafficking in Ab generation.

Make a Comment

To make a comment you must login or register.