. Association of Antioxidant Supplement Use and Dementia in the Prevention of Alzheimer's Disease by Vitamin E and Selenium Trial (PREADViSE). JAMA Neurol. 2017 May 1;74(5):567-573. PubMed.

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  1. This study is based on the a priori hypothesis that oxidative stress is a key player in the progression of AD. It comes at a time when an emerging body of literature suggests that hyperactivity may play a greater role in this neurodegenerative disease than does oxidative stress. In any age-related neurodegenerative disease, the major factor influencing risk and age at onset is "age" per se. At best, interventions should be expected to slow disease progression by 0-15 percent, and then only if these are initiated early enough in life to sufficiently modify the subclinical course and thus, delay disease onset. Since the effect size is small relative to the idiopathic variance in age at onset, detecting an effect in these studies is difficult due to sample size. This debate will therefore likely continue for far too many years to come to have any meaningful impact on the incidence of AD in our aging populations. In the meantime, it seems prudent to take good care of your overall health with the expectation that this will improve the overall quality of your life and delay onset of any diseases you are genetically predisposed to develop. 

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