Schott JM, Fox NC, Frost C, Scahill RI, Janssen JC, Chan D, Jenkins R, Rossor MN.
Assessing the onset of structural change in familial Alzheimer's disease.
Ann Neurol. 2003 Feb;53(2):181-8.
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Another nice study from this group. These longitudinal data provide insight into the rates of brain atrophy in patients with familial AD. They reinforce the notion that a lot of damage occurs prior to clinically recognized disease. If true for typical late onset AD such studies have important implications regarding implementation of disease modifying therapies.