Arterial stiffness as a potential determinant of β-amyloid deposition.
JAMA Neurol. 2014 May;71(5):541-2.
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This extremely interesting research points out the existence of a close correlation between capillary and microcirculatory blood flow in the brain and the process of amyloid accumulation in the cerebral tissue. The authors say that the deterioration of capillary blood flow enhances the deposition of amyloid in the cerebral tissue. These studies confirm our earlier work [1, 2, 3] that showed the presence of dyscirculatory angiopathy of Alzheimer's type (DAAT) in patients with AD, which leads to serious disorders of capillary blood flow in the brain and not only promotes the accumulation of Aβ in the cerebral tissue but also reduces its excretion, which was noted by Professor B. Zlokovic as well .
Dyscirculatory Angiopathy of Alzheimer's Type.
Journal of Behavioral and Brain Science, 2011, Vol.1(2), pp. 57-68.
Vascular factors in Alzheimer’s disease.
J. Health. 4, Special Issue I, 735-742.
Disorders of cerebrovascular angioarchitectonics and microcirculation in the etiology and pathogenesis of Alzheimer’s disease.
Advances in Alzheimer’s Disease, 2, 4, 2013, 171-181.
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders.
Nat Rev Neurosci. 2011 Dec;12(12):723-38.