. The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. J Cell Sci. 2004 Sep 1;117(Pt 19):4435-48. PubMed.


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  1. From this paper, one should ask—if AICD is dysregulated in AD—if yes, if this dysregulation is playing a role in the neurodegenerating process (loss of function of APP due to aberrrant nuclear signalling), and if amyloid is not a marker of this dysmetabolism.

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