This paper proposes that the relationship between apo E and AD revolves around their statement that 'During dendritic remodelling and synaptogenesis, neurons progressively repress the synthesis of cholesterol in favor of cholesterol internalization through the apoE/LDL receptor pathway.' and that 'a dysfunction of the lipid transport system associated with compensatory sprouting and synaptic remodelling could be central to the AD process.' However, several studies suggest that apo E genotype may not influence parameters elated to dendritic remodelling.
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Banner Research Institute
This paper proposes that the relationship between apo E and AD revolves around their statement that 'During dendritic remodelling and synaptogenesis, neurons progressively repress the synthesis of cholesterol in favor of cholesterol internalization through the apoE/LDL receptor pathway.' and that 'a dysfunction of the lipid transport system associated with compensatory sprouting and synaptic remodelling could be central to the AD process.' However, several studies suggest that apo E genotype may not influence parameters elated to dendritic remodelling.
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