. Apolipoprotein e genotype modifies the phenotype of Alzheimer disease. Arch Neurol. 2006 Jan;63(1):155-6. PubMed.

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  1. The authors show that, despite a relatively earlier age of onset, AD dementia patients with a more posterior pattern of atrophy do not have a particular over-representation of apoE4 in a small sample. If this proves true, it suggests that another genetic risk factor may be at play that both drives earlier age of onset and the posterior phenotype. The concept is intriguing, especially when applied to the more general question of why some patients present with aphasia or have an unusual pattern of specific vulnerability.