. Apolipoprotein E epsilon4 allele, AD pathology, and the clinical expression of Alzheimer's disease. Neurology. 2003 Jan 28;60(2):246-52. PubMed.

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  1. Clinical-Pathologic data that supports the hypothesis that APOE4 casues AD by influencing Abeta deposition. A nice example of how genetic, biochemical, pathologic, and animal modeling studies converge to support a unifying hypothesis.