. The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture. J Neurochem. 2001 Sep;78(5):1168-78. PubMed.

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  1. Recent reports indicate that the C-terminus of APP can stimulate gene transcription. This study provides support for the connection between APP and gene transcription by showing that APP can be observed in the nucleus.