. Amyloid deposits in the cerebral cortex of patients with Alzheimer's disease align with cytoarchitectonic properties. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;

Abstract:

Background: According to Braak and Braak stage, the amyloid deposits in the post-mortem AD brains are not distributed at random but show a characteristic pattern. They differ in both topographical and neuroanatomical perspectives reaching from basal portions of the isocortex through all isocortical association areas to primary sensory and motor cortices. Of particular a predilection of laminar preference for amyloid deposits is also noticeable. The above characterizations of amyloid distributions are purely derived from mapping on the post-mortem human tissues. Today the introduction of in vivo visualizing the amyloid deposits using 11C-PIB in PET technique has made it possible to gain further insight into the neuropathological characterization of AD in their living brains. However (1) a comprehensive mapping of amyloid deposits regarding the cytoarchitecture of the cerebral cortex, and (2) whether the pathological consequences of amyloid deposits within particular type of cerebral cortex appear more indicative of mental decline remain unanswered.

Methods: To address such questions, a cytoarchitectonic probabilistic map whose cytoarchitectonic borders are scientifically testable by an observer- independent approach was for the first time used to quantitatively measuring amyloid deposits across cortical types in AD, MCI PIB+, MCI PIB-, and control subjects. Six cortical types including granular, dysgranular, agranular, allocortex, periallocortex, and corticoid are classified.

Results: Our findings demonstrated a marked variability between AD and MCI PIB- group, and control group for the amount of amyloid deposits for most cortical types, except in allocortex and corticoid, which were nearly invariant between AD and control groups. The amyloid deposits in MCI PIB+ group was significantly greater than those who were PIB- in all cytoarchitectures, with the exception of corticoid.

Conclusions: The amount of amyloid deposits in selective cytoarchitecture differed among groups, suggesting possible disruption of neural transmission involving a large scale of cerebral cortex link the severity of the disease.

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