Rentz DM, Betensky RA, Becker JA, England RL, Maye J, Gidicsin C, Sperling RA, Johnson KA.
Amyloid deposition in non-demented elderly predicts longitudinal cognitive decline.
Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
Background: Amyloid-beta (As) deposition measured with PiB PET has been observed in a large fraction of nondemented
individuals, but it is unknown whether As burden means further decline toward Alzheimer's disease (AD)
Objective: We tested whether PiB retention in non-demented subjects predicts longitudinal decline in
neuropsychological (NP) performance and whether cognitive reserve (CR) continues to modify the relationship
Methods: Seventy-four non-demented older subjects (CDR 0 n = 47, age 75.2) 7y, CDR 0.5 n = 27, age 75.8} 7y);
underwent PiB PET at baseline and neuropsychological assessments at baseline and follow-up (mean duration,
18.6 months). PiB retention was expressed as mean cortical DVR, cerebellar reference, measured in the precuneus/
posterior cingulate. Multivariate models related PiB retention at baseline with change in neuropsychological test
scores from baseline to follow-up, controlling for CDR 0 versus 0.5, age and cognitive reserve (CR, education as
Results: Higher PiB retention predicted greater decline in subjects with lower CR, on cued recall (MC30, FCSRT
p Conclusions: These findings suggest that As deposition at baseline in non-demented individuals predicts decline
in cognitive domains commonly impaired in AD dementia. High CR contributes to cognitive stability and low CR
portends decline with age, regardless of PiB status. Additional longitudinal data is required to determine whether
subjects with As burden and NP decline will meet criteria for AD dementia.