. Amyloid-beta peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release. Brain Res. 1998 Mar 2;785(2):195-206. PubMed.

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  1. Hu et al report that amyhloid-beta activates cultured astrocytes and conclude that "A-beta plays a role in the reactive astrocytosis of AD and that the inflammatory response induced upon glial activation is a critical component of the neurodegenerative process." The findings do not shed light on causal mechanisms but rather describe the role of glia as reactors to the neurodegenerative process.

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