. The Alzheimer's disease mitochondrial cascade hypothesis. J Alzheimers Dis. 2010;20 Suppl 2:S265-79. PubMed.

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  1. A link among mitochondrial dysfunction, tau, and Aβ has also been established in transgenic mice by combining quantitative proteomics with functional assays.

    References:

    . Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20057-62. PubMed.

    . Oligomeric and fibrillar species of beta-amyloid (A beta 42) both impair mitochondrial function in P301L tau transgenic mice. J Mol Med (Berl). 2008 Nov;86(11):1255-67. PubMed.

    . Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice. J Biol Chem. 2005 Jun 24;280(25):23802-14. PubMed.

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