. Alzheimer's disease: From big data to mechanism. Nature. 2013 Aug 1;500(7460):34-5. PubMed.


Please login to recommend the paper.


  1. I read this paper with keen interest yesterday, but also found myself uneasy with the recombinant ApoE cell treatments as noted by Sam Gandy. Following my reading of his comments today, I took another look at that paper with a different view, asking if these points diminished my initial enthusiasm. I arrived at the conclusion that even if all of the recombinant ApoE treatment studies were removed from the paper as potentially artifactual, the conclusions of the authors still stand on the basis of the differential co-expression analyses and the experiments with the human induced neuronal cultures.

    View all comments by Barry Greenberg

Make a Comment

To make a comment you must login or register.

This paper appears in the following:


  1. A Genetic Approach to the ApoE4 Puzzle
  2. ApoE4 Paper Retracted from Nature