. Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice. J Neurochem. 1999 Mar;72(3):1030-9. PubMed.


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  1. The paper shows that calcium ion is another central molecule besides superoxide for amyloid hypothesis.

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  1. PS1(M146L)
  2. PS1(M146V)