. alpha-Synuclein locus triplication causes Parkinson's disease. Science. 2003 Oct 31;302(5646):841. PubMed.


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  1. This is a key paper in establishing the role of synuclein and synuclein misfolding in Parkinson disease. It is analagous to the situation in AD, where there is trisomy 21 and, more recently, focal triplications of APP.