Fernagut PO, Chesselet MF.
Alpha-synuclein and transgenic mouse models.
Neurobiol Dis. 2004 Nov;17(2):123-30.
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The study of Lewy body disorders will be greatly advanced with the development and characterization of transgenic mouse models. Although most lines overexpress alpha-synuclein, not all lines have necessarily recapitulated LB-like pathology. It is also unfortunate that it has been difficult to model dopaminergic neuron loss such as seen in Parkinson's disease. This review gives a nice overview of what has been done and (hopefully) can stimulate some bright investigator to figure out what we are all doing wrong.