The paper aims to understand a novel physiological function of LRRK2 by mingling with the mutant α-synuclein protein. The approach seems fascinating. The authors plausibly suggest a link between LRRK2 and AD via the microtubule binding protein tau. However, several mechanisms run in parallel between AD and PD. The question arises whether it is a single disease with multiple kinds of dysfunction or multiple disorders?
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Johns Hopkins University School of Medicine
The paper aims to understand a novel physiological function of LRRK2 by mingling with the mutant α-synuclein protein. The approach seems fascinating. The authors plausibly suggest a link between LRRK2 and AD via the microtubule binding protein tau. However, several mechanisms run in parallel between AD and PD. The question arises whether it is a single disease with multiple kinds of dysfunction or multiple disorders?
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