. alpha-synuclein and LRRK2: partners in crime. Neuron. 2009 Dec 24;64(6):771-3. PubMed.


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  1. The paper aims to understand a novel physiological function of LRRK2 by mingling with the mutant α-synuclein protein. The approach seems fascinating. The authors plausibly suggest a link between LRRK2 and AD via the microtubule binding protein tau. However, several mechanisms run in parallel between AD and PD. The question arises whether it is a single disease with multiple kinds of dysfunction or multiple disorders?

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  1. α-Synuclein Conspires With LRRK2 to Corrupt Neurons