. Allele-specific silencing of Alzheimer's disease genes: the amyloid precursor protein genes with Swedish or London mutations. Gene. 2006 Apr 12;371(1):68-74. PubMed.

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  1. This work takes a step forward in understanding allele-specific silencing, a goal that may have importance in several neurodegenerative diseases. The recent work with turning off the tau transgene leading to behavioral improvement in mice also may suggest the possibility that silencing of non-mutant alleles could have some therapeutic benefit in AD, or in circumstances like Down syndrome or synuclein triplication where overexpression appears to be a major issue.