Add Alzheimer's disease to the list of autoimmune diseases.
Med Hypotheses. 2005;64(3):458-63.
Please login to recommend the paper.
Make a Comment
We should be cautious in how we classify AD. It is heterogenic, with more genes being discovered all the time to increase risk of developing this pathology or something similiar; there is also clinical overlap. Yes, AD shows autotoxicity, including increase in Ig in respective brain regions, cerebral encephalitis and dysfuntion in blood brain barrier. To state, however, in such a way that amyloid and neurofibrillary tangles do not independently (and quite effectively, I might add) destroy neurons and that AD should have the overall heading of autoimmune disease is both unscientific and premature.
I must agree that an awry immune response targeting amyloid protein plays an integral role in cerebral dysfunction. And I am aware that the narrow view some immunologists take of signs of inflammation, i.e. heat, redness, swelling, and pain, need not apply here. I am convinced that amyloid beta oxidation of neurons requires not only immune responses such as nitric oxide free radicals and radical oxygen species to perform as an efficient killer of neurons. I welcome comments and any related AD information through email to email@example.com.
To make a comment you must login or register.