. Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2720-5. PubMed.


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  1. Given the recent papers on nicastrin knockout flies, this is the predicted result. Even before this paper, there is plenty of evidence to argue that the other ps interacting proteins, especially β-catenin, is not involved in the gamma activity.

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  1. Would the Real γ-Secretase Please Stand Up