. Is abnormal axonal transport a cause, a contributing factor or a consequence of the neuronal pathology in Alzheimer's disease?. Future Neurol. 2009 Nov 1;4(6):761-773. PubMed.

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  1. The authors state that “perturbation of the transport of a limited set of proteins has been occasionally reported for other neurodegenerative diseases [than Alzheimer's].” In fact, we have shown that the anterograde transport of distinct cargos is impaired in our K369I tau transgenic K3 mice and in Alzheimer disease brain.

    References:

    . Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15997-6002. Epub 2008 Oct 2 PubMed.

    . Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease. J Biol Chem. 2009 Jul 31;284(31):20909-16. PubMed.