Sheta EA, Appel SH, Goldknopf IL.
2D gel blood serum biomarkers reveal differential clinical proteomics of the neurodegenerative diseases.
Expert Rev Proteomics. 2006 Feb;3(1):45-62.
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This review appears to marshall evidence for the power of multivariate analyses in the distinction of neurodegenerative disease. Many issues remain, including sensitivity and specificty of these approaches.