View our list of seminal publications tracing the intellectual evolution of the Alzheimer's disease field.
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Milestone Papers
1 to 20 of 286 results
Yaffe K, Kanaya A, Lindquist K, Simonsick EM, Harris T, Shorr RI, Tylavsky FA, Newman AB. The metabolic syndrome, inflammation, and risk of cognitive decline.JAMA.
2004 Nov 10;292(18):2237-42.
Pubmed Abstract
Hirsch-Reinshagen V, Zhou S, Burgess BL, Bernier L, McIsaac SA, Chan JY, Tansley GH, Cohn JS, Hayden MR, Wellington CL. Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain.J Biol Chem.
2004 Sep 24;279(39):41197-207.
Pubmed Abstract
Wahrle SE, Jiang H, Parsadanian M, Legleiter J, Han X, Fryer JD, Kowalewski T, Holtzman DM. ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.J Biol Chem.
2004 Sep 24;279(39):40987-93.
Pubmed Abstract
Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J, Yankner BA. Gene regulation and DNA damage in the ageing human brain.Nature.
2004 Jun 24;429(6994):883-91.
Pubmed Abstract
Kopan R, Ilagan MX. Gamma-secretase: proteasome of the membrane?Nat Rev Mol Cell Biol.
2004 Jun ;5(6):499-504.
Pubmed Abstract
Petrucelli L, Dickson D, Kehoe K, Taylor J, Snyder H, Grover A, De Lucia M, McGowan E, Lewis J, Prihar G, Kim J, Dillmann WH, Browne SE, Hall A, Voellmy R, Tsuboi Y, Dawson TM, Wolozin B, Hardy J, Hutton M. CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation.Hum Mol Genet.
2004 Apr 1;13(7):703-14.
Pubmed Abstract
Greicius MD, Srivastava G, Reiss AL, Menon V. Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI.Proc Natl Acad Sci U S A.
2004 Mar 30;101(13):4637-42.
Pubmed Abstract
Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, Bergström M, Savitcheva I, Huang GF, Estrada S, Ausén B, Debnath ML, Barletta J, Price JC, Sandell J, Lopresti BJ, Wall A, Koivisto P, Antoni G, Mathis CA, Långström B. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.Ann Neurol.
2004 Mar ;55(3):306-19.
Pubmed Abstract
Demattos RB, Cirrito JR, Parsadanian M, May PC, O'Dell MA, Taylor JW, Harmony JA, Aronow BJ, Bales KR, Paul SM, Holtzman DM. ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.Neuron.
2004 Jan 22;41(2):193-202.
Pubmed Abstract
Tariot PN, Farlow MR, Grossberg GT, Graham SM, McDonald S, Gergel I, . Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial.JAMA.
2004 Jan 21;291(3):317-24.
Pubmed Abstract
Reiman EM, Chen K, Alexander GE, Caselli RJ, Bandy D, Osborne D, Saunders AM, Hardy J. Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia.Proc Natl Acad Sci U S A.
2004 Jan 6;101(1):284-9.
Pubmed Abstract
Gong Y, Chang L, Viola KL, Lacor PN, Lambert MP, Finch CE, Krafft GA, Klein WL. Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss.Proc Natl Acad Sci U S A.
2003 Sep 2;100(18):10417-22.
Pubmed Abstract
Eriksen JL, Sagi SA, Smith TE, Weggen S, Das P, McLendon DC, Ozols VV, Jessing KW, Zavitz KH, Koo EH, Golde TE. NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo.J Clin Invest.
2003 Aug ;112(3):440-9.
Pubmed Abstract
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, Laferla FM. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction.Neuron.
2003 Jul 31;39(3):409-21.
Pubmed Abstract
Aisen PS, Schafer KA, Grundman M, Pfeiffer E, Sano M, Davis KL, Farlow MR, Jin S, Thomas RG, Thal LJ, . Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial.JAMA.
2003 Jun 4;289(21):2819-26.
Pubmed Abstract
Shumaker SA, Legault C, Rapp SR, Thal L, Wallace RB, Ockene JK, Hendrix SL, Jones BN, Assaf AR, Jackson RD, Kotchen JM, Wassertheil-Smoller S, Wactawski-Wende J, . Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial.JAMA.
2003 May 28;289(20):2651-62.
Pubmed Abstract
Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ. Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.Proc Natl Acad Sci U S A.
2003 May 27;100(11):6382-7.
Pubmed Abstract
Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C. Reconstitution of gamma-secretase activity.Nat Cell Biol.
2003 May ;5(5):486-8.
Pubmed Abstract
Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis.Science.
2003 Apr 18;300(5618):486-9.
Pubmed Abstract
De Strooper B. Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex.Neuron.
2003 Apr 10;38(1):9-12.
Pubmed Abstract
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