Alzforum: Papers of the Week

Defina LF, Willis BL, Radford NB, Gao A, Leonard D, Haskell WL, Weiner MF, Berry JD. The association between midlife cardiorespiratory fitness levels and later-life dementia: a cohort study. Ann Intern Med. 2013 Feb 5;158(3):162-8. PubMed Abstract

Honarnejad K, Jung CK, Lammich S, Arzberger T, Kretzschmar H, Herms J. Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease. J Cell Mol Med. 2013 Feb 5; PubMed Abstract

Mori K, Lammich S, Mackenzie IR, Forné I, Zilow S, Kretzschmar H, Edbauer D, Janssens J, Kleinberger G, Cruts M, Herms J, Neumann M, Van Broeckhoven C, Arzberger T, Haass C. hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations. Acta Neuropathol. 2013 Feb 5; PubMed Abstract

Delbeuck X, Debachy B, Pasquier F, Moroni C. Action and noun fluency testing to distinguish between Alzheimer's disease and dementia with Lewy bodies. J Clin Exp Neuropsychol. 2013 Feb 4; PubMed Abstract

Silva D, Chioua M, Samadi A, Agostinho P, Garção P, Lajarín-Cuesta R, de los Ríos C, Iriepa I, Moraleda I, Gonzalez-Lafuente L, Mendes E, Pérez C, Rodríguez-Franco MI, Marco-Contelles J, Carmo Carreiras M. Synthesis, Pharmacological Assessment, and Molecular Modeling of Acetylcholinesterase/Butyrylcholinesterase Inhibitors: Effect against Amyloid-β-Induced Neurotoxicity. ACS Chem Neurosci. 2013 Feb 4; PubMed Abstract

Singh N, Haldar S, Beveridge AJ, Wong J, Singh A, Galimberti D, Borroni B, Zhu X, Blevins J, Greenlee JJ, Perry G, Mukhopadhyay C, Schmotzer C. A low molecular-weight ferroxidase is increased in the CSF of sCJD cases: CSF ferroxidase and transferrin as diagnostic biomarkers for sCJD. Antioxid Redox Signal. 2013 Feb 4; PubMed Abstract

Arnold ES, Ling SC, Huelga SC, Lagier-Tourenne C, Polymenidou M, Ditsworth D, Kordasiewicz HB, McAlonis-Downes M, Platoshyn O, Parone PA, Da Cruz S, Clutario KM, Swing D, Tessarollo L, Marsala M, Shaw CE, Yeo GW, Cleveland DW. ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43. Proc Natl Acad Sci U S A. 2013 Feb 4; PubMed Abstract

Wickner RB, Edskes HK, Bateman DA, Kelly AC, Gorkovskiy A, Dayani Y, Zhou A. Amyloids and yeast prion biology. Biochemistry. 2013 Feb 4; PubMed Abstract

Perez PD, Hall G, Kimura T, Ren Y, Bailey RM, Lewis J, Febo M, Sahara N. In vivo functional brain mapping in a conditional mouse model of human tauopathy (taup301l) reveals reduced neural activity in memory formation structures. Mol Neurodegener. 2013 Feb 4;8(1):9. PubMed Abstract

Park L, Zhou J, Zhou P, Pistick R, El Jamal S, Younkin L, Pierce J, Arreguin A, Anrather J, Younkin SG, Carlson GA, McEwen BS, Iadecola C. Innate immunity receptor CD36 promotes cerebral amyloid angiopathy. Proc Natl Acad Sci U S A. 2013 Feb 4; PubMed Abstract

Walton JR. Aluminum Involvement in the Progression of Alzheimer's Disease. J Alzheimers Dis. 2013 Feb 4; PubMed Abstract

Merrill DA, Siddarth P, Kepe V, Raja PV, Saito N, Ercoli LM, Miller KJ, Lavretsky H, Bookheimer SY, Barrio JR, Small GW. Vascular Risk and FDDNP-PET Influence Cognitive Performance. J Alzheimers Dis. 2013 Feb 4; PubMed Abstract

Scahill RI, Ridgway GR, Bartlett JW, Barnes J, Ryan NS, Mead S, Beck J, Clarkson MJ, Crutch SJ, Schott JM, Ourselin S, Warren JD, Hardy J, Rossor MN, Fox NC. Genetic Influences on Atrophy Patterns in Familial Alzheimer's Disease: A Comparison of APP and PSEN1 Mutations. J Alzheimers Dis. 2013 Feb 4; PubMed Abstract

Pottier C, Wallon D, Rousseau S, Rovelet-Lecrux A, Richard AC, Rollin-Sillaire A, Frebourg T, Campion D, Hannequin D. TREM2 R47H Variant as a Risk Factor for Early-Onset Alzheimer's Disease. J Alzheimers Dis. 2013 Feb 4; PubMed Abstract

Goncalves MB, Clarke E, Hobbs C, Malmqvist T, Deacon R, Jack J, Corcoran JP. Amyloid β inhibits retinoic acid synthesis exacerbating Alzheimer disease pathology which can be attenuated by an retinoic acid receptor α agonist. Eur J Neurosci. 2013 Feb 4; PubMed Abstract

Vermeiren AP, Bosma H, Visser PJ, Zeegers MP, Graff C, Ewers M, Frisoni GB, Frölich L, Hampel H, Jones RW, Kehoe PG, Lenoir H, Minthon L, Nobili FM, Olde Rikkert M, Rigaud AS, Scheltens P, Soininen H, Spiru L, Tsolaki M, Wahlund LO, Vellas B, Wilcock G, Elias-Sonnenschein LS, Verhey FR. The Association Between APOE ε4 and Alzheimer-type Dementia among Memory Clinic Patients is Confined to those with a Higher Education. The DESCRIPA Study. J Alzheimers Dis. 2013 Feb 4; PubMed Abstract

Steele JW, Gandy S. Latrepirdine (Dimebon (®) ), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model. Autophagy. 2013 Feb 4;9(4) PubMed Abstract

Lane RF, Dacks PA, Shineman DW, Fillit HM. Diverse therapeutic targets and biomarkers for Alzheimer's disease and related dementias: report on the Alzheimer's Drug Discovery Foundation 2012 International Conference on Alzheimer's Drug Discovery. Alzheimers Res Ther. 2013 Feb 4;5(1):5. PubMed Abstract

Sayed N, Culver C, Dams-O'Connor K, Hammond F, Diaz-Arrastia R. Clinical Phenotype of Dementia after Traumatic Brain Injury. J Neurotrauma. 2013 Feb 4; PubMed Abstract

Jin J, Albertz J, Guo Z, Peng Q, Rudow G, Troncoso JC, Ross CA, Duan W. Neuroprotective effects of PPAR-γ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease. J Neurochem. 2013 Feb 4; PubMed Abstract

Hochfeld WE, Lee S, Rubinsztein DC. Therapeutic induction of autophagy to modulate neurodegenerative disease progression. Acta Pharmacol Sin. 2013 Feb 4; PubMed Abstract

Bigio EH, Wu JY, Deng HX, Bit-Ivan EN, Mao Q, Ganti R, Peterson M, Siddique N, Geula C, Siddique T, Mesulam M. Inclusions in frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP) and amyotrophic lateral sclerosis (ALS), but not FTLD with FUS proteinopathy (FTLD-FUS), have properties of amyloid. Acta Neuropathol. 2013 Feb 3; PubMed Abstract

Chhangani D, Mishra A. Protein Quality Control System in Neurodegeneration: A Healing Company Hard to Beat but Failure is Fatal. Mol Neurobiol. 2013 Feb 3; PubMed Abstract

Blandini F. Neural and Immune Mechanisms in the Pathogenesis of Parkinson's Disease. J Neuroimmune Pharmacol. 2013 Feb 3; PubMed Abstract

Cerami C, Cappa SF. The behavioral variant of frontotemporal dementia: linking neuropathology to social cognition. Neurol Sci. 2013 Feb 3; PubMed Abstract