Ong K, Villemagne VL, Bahar-Fuchs A, Lamb F, Reininger C, Putz B, Rohde B, Masters CL, Rowe CC.
A Two-Year Longitudinal Assessment of Aβ Deposition in Late MCI with8F-Florbetaben.Human Amyloid Imaging Abstract.
2012 Jan 1;
ABSTRACT
Objective: Assess Aβ deposition longitudinally in subjects with Mild Cognitive Impairment (MCI) and explore its relationship with cognition and disease progression.
Methods: Forty-five MCI subjects were followed up for4 months after their first8F-Florbetaben PET (FBB-PET) scan. Every participant underwent a comprehensive clinical and neuropsychological examination every months and a FBB-PET scan every year. Aβ burden was quantified using SUVR employing the cerebellar cortex as reference region.
Results: At baseline/45 (53%) of the MCI participants presented with high neocortical FBB retention. There was a strong relationship between neocortical SUVR and composite memory scores (r=-0.60, p<0.0001), as well as MMSE (r = -0.41, p < 0.008). At4-month follow-up, small but significant increases in neocortical FBB SUVR were observed in MCI with high-FBB retention at baseline (+2.4%, p=0.02). Progression to AD occurred in9% of MCI with high-FBB, with4% of the low-FBB MCI subjects progressing to other dementias. One low-FBB MCI developed mixed dementia.
Conclusions: Aβ deposition is a slow process that precedes severe cognitive impairment. Extensive Aβ deposition is associated with a significant higher risk of progression from MCI to AD over years.8F-Florbetaben-PET is a sensitive technique to longitudinally assess Aβ deposition in the brain.
