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Wolfe M. on PAPER: Coric V. et al., 2012, These cognitive effects, along with the adverse events in the gastrointestinal tract and skin,... 21 Nov 2012.
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Wolfe M. on PAPER: Hu J. et al., 2011, This paper describes the detailed structure of a membrane-embedded aspartyl protease called... 26 Jul 2011.
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Wolfe M. on PAPER: Morris MC. et al., 2010, Recommendation Only. 2 Jul 2010.
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Wolfe M. on PAPER: Fukumori A. et al., 2010, This is a solid study that provides important confirmation that presenilin is a zymogen that... 29 Jun 2010.
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Wolfe M. on PAPER: Watanabe N. et al., 2010, This report provides a very thorough and systematic analysis of the role of the various... 30 Apr 2010.
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Wolfe M. on PAPER: Page RM. et al., 2010, The new report by Page et al. describes important results that address the controversial issue... 6 Apr 2010.
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Wolfe M. on PAPER: Tian Y. et al., 2010, This is an intriguing paper describing the surprising discovery that a stretch of 4-7 amino... 14 Jan 2010.
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Wolfe M. on NEWS: Dual Secretase Approach Shows Promise in AD Mice, The new study by Chow and colleagues describes evidence that the combination of partial... 13 Jan 2010.
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Wolfe M. on PAPER: Takami M. et al., 2009, This is an excellent study that describes missing pieces in the puzzle of γ-secretase: the... 6 Jan 2010.
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Wolfe M. on PAPER: Serneels L. et al., 2009, This paper describes the role of the different Aph1 subtypes in the production of Aβ and in... 6 Jan 2010.
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Wolfe M. on PAPER: Loane DJ. et al., 2009, This paper is on how blocking Aβ production may help treat traumatic brain injury. With respect... 6 Jan 2010.
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Wolfe M. on PAPER: Thathiah A. et al., 2009, This paper is on the identification of a novel receptor that can regulate Aβ production. The... 6 Jan 2010.
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Wolfe M. on PAPER: Laurén J. et al., 2009, This paper reports the surprising identification by expression cloning of the prion protein... 6 Jan 2010.
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Wolfe M. on PAPER: Nikolaev A. et al., 2009, This paper provides extensive and compelling evidence for β-APPs (shed from the cell surface by... 6 Jan 2010.
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Wolfe M. on PAPER: Wakabayashi T. et al., 2009, This is an excellent study by the De Strooper lab, using a biochemical approach to identify... 23 Oct 2009.
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Wolfe M. on NEWS: Research Brief: APP Unraveled—Structural Model Extols ε Cleavage, Sato et al. provide nice evidence that APP residues 618-660 can form a dimer...under conditions... 24 Jan 2009.
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Wolfe M. on NEWS: Research Brief: Gain or Loss of Function? Ataxin Mutation Cuts Both Ways, This report provides evidence that 1) disease-causing polyglutamine expansion in ataxin-1 can... 15 Mar 2008.
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Wolfe M. on PAPER: Czirr E. et al., 2007, In this paper, Czirr and colleagues report that presenilin mutations that cause severe,... 29 Jun 2007.
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Wolfe M. on What We Know, What We Don't Know, I would add that we know that presenilin is the catalytic component of gamma-secretase and thus... 12 Feb 2007.
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Wolfe M. on PAPER: Lanz TA. et al., 2006, This thorough study from researchers at Pfizer demonstrates that a γ-secretase inhibitor... 10 Sep 2006.
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Wolfe M. on NEWS: Nicastrin—A DAPper Role in γ-Secretase, This is an excellent study from the lab of Gang Yu, the original discoverer of nicastrin as a... 19 Aug 2005.
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Wolfe M. on NEWS: No Toxicity in Tau’s Tangles?, I found this paper fascinating and very intriguing, but could not determine whether the effects... 26 Jul 2005.
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Wolfe M. on PAPER: Zhao G. et al., 2004, The findings in the paper by Zhao and colleagues are intriguing: The presence of a 46-residue... 14 Jan 2005.
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Wolfe M. on PAPER: Ishikura N. et al., 2005, This article shows that the Notch intracellular domain (NICD), the proteolytic fragment that... 11 Jan 2005.
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Wolfe M. on NEWS: Erene Mina Reports on Presenilin’s Loops through the Membrane, This paper revisits the issue of presenilin topology, providing further evidence of a 7-TM model... 23 Jan 2004.
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Selkoe D, Wolfe M, Xia W. on PAPER: Netzer WJ. et al., 2003, The findings of Netzer and colleagues that Gleevec and related protein kinase inhibitors can... 9 Oct 2003.
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Wolfe M. on NEWS: Nicastrin Mutations Selectively Modulate Notch Processing, The results of this paper are very interesting and emphasize the critical role of nicastrin in... 24 Oct 2002.
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Wolfe M. on NEWS: Presenilin—Guilty of Proteolysis by Association?, Reply by Michael Wolfe
As Sam Sisodia and Bart De Strooper point out in their... 23 Jun 2002.
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1 to 28 of 28 results |
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