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1 to 30 of 31 results |
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Pimplikar S. on NEWS: Does ApoE4 Lower Brain Metabolism Independently of Aβ?, The finding that ApoE4 carriers display Aβ-independent pathomechanisms is not really... 19 Dec 2012.
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Pimplikar S. on NEWS: CTAD: New Data on Sola, Bapi, Spark Theragnostics Debate, The fact that there is a silver lining to the solanezumab trial is welcome news, even though it... 3 Dec 2012.
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Pimplikar S. on NEWS: Enter the New Alzheimer’s Gene: TREM2 Variant Triples Risk, With the increasing acceptance (1) that Alzheimer’s disease is a multifactorial disorder (2), it... 26 Nov 2012.
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Pimplikar S. on PAPER: Lauritzen I. et al., 2012, This study from the Checler group provides compelling evidence that 3xTg mice accumulate the C99... 17 Nov 2012.
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Pimplikar S. on NEWS: In Cells, Late- and Early-Onset Alzheimer’s Look Different, This study by Bali et al. provides compelling evidence that downregulation of the late-onset AD... 13 Sep 2012.
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Pimplikar S. on NEWS: Protective APP Mutation Found—Supports Amyloid Hypothesis, This study provides elegant genetic evidence that reducing the BACE processing of APP protects... 24 Jul 2012.
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Pimplikar S. on PAPER: Barten DM. et al., 2012, Coming hard on the heels of the work by Brunden and colleagues (Zhang et al., 2012), this study... 30 May 2012.
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Pimplikar S. on NEWS: NIH Director Announces $100M Prevention Trial of Genentech Antibody, The news that Genentech is providing major funding to support the upcoming prevention trial in... 23 May 2012.
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Pimplikar S. on NEWS: Biomarker Duo Signals Mental Decline, The conclusion that elevated CSF p-tau levels with reduced Aβ levels (Aβ+/p-tau+) are better... 15 May 2012.
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Pimplikar S. on NEWS: Antioxidants No Help for Alzheimer’s, Biomarker Trial Says, These conclusions are based on a four-month treatment, whereas most trials go on for 18 months,... 25 Mar 2012.
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Pimplikar S. on PAPER: Sperling RA. et al., 2011, Sperling et al. have put forward a now familiar argument (also proposed by others; 1-4) that... 7 Dec 2011.
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Pimplikar S. on NEWS: Aggressive Diabetes Treatment Slows Atrophy But Not Mental Slide, Alzforum should be commended for highlighting the ACCORD MIND study. At first glance, the... 12 Oct 2011.
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Pimplikar S. on PAPER: Cheng N. et al., 2011, In my view, the importance of this study lies in the finding that APP-induced neurodegeneration... 10 Oct 2011.
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Pimplikar S. on NEWS: Can Diet Influence Alzheimer’s Disease Biomarkers?, These are interesting studies, and the conclusions drawn by the authors, though based on a... 27 Jun 2011.
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Pimplikar S. on PAPER: Winton MJ. et al., 2011, It is a healthy sign that the paper by Winton et al. has initiated a debate over intraneuronal... 10 Jun 2011.
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Pimplikar S. on PAPER: Ioannidis JP. et al., 2011, The remarkable, if not entirely surprising, findings reported in this paper should be of... 9 Jun 2011.
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Pimplikar S. on PAPER: Swistowski A. et al., 2009, This study from Dale Bredesen’s group identifies TAZ and YAP as two potential downstream agents... 5 Jan 2010.
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Pimplikar S. on NEWS: APP Tail May Wag DNA Repair Pathway, This report from Tommaso Russo’s group represents a small but growing number of studies that are... 19 Mar 2009.
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Pimplikar S. on NEWS: Keystone: Death Receptor Ligand—New Role for APP, New Model for AD?, Reading this remarkable paper from the Tessier-Lavigne group feels like drinking water from a... 3 Mar 2009.
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Pimplikar S. on NEWS: Research Brief—Flurizan Fails Final Hurdle, Company Discontinues Drug, Flurizan Trial: Sic Transit Gloria Mundi
The news that the Phase 3 trial of... 3 Jul 2008.
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Pimplikar S. on NEWS: San Diego: Oligomers Live Up to Bad Reputation, Part 1, Alzheimer Disease, Aβ Oligomers, and Shrek
Gabrielle Strobel and Alzforum should be... 26 Nov 2007.
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Pimplikar S. on PAPER: Liu Q. et al., 2007, AICD Rules!
Coming on the heels of the report that AICD represses transcription of... 10 Oct 2007.
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Pimplikar S. on LIVE DISCUSSION: APP Family: Clues to Function in Health and AD
, Response to comment by Vincent Marchesi
Dr. Marchesi correctly captures the essence... 9 Oct 2007.
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Pimplikar S. on NEWS: How Does Aβ Do Harm? New Clues on Insulin Signaling, Spines, Inflammation, The two papers that report the effects of “oligomeric” Aβ on insulin signaling pathways display... 18 Sep 2007.
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Pimplikar S. on PAPER: Ring S. et al., 2007, A Case of “Heads Win, Tails Don’t Lose”
The progress in uncovering the function of... 3 Aug 2007.
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Pimplikar S. on PAPER: Zhang YW. et al., 2007, Whether or not AICD plays a transcriptional regulatory role has been much debated since the... 21 Jun 2007.
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Pimplikar S. on PAPER: Nakaya T. et al., 2006, To Bind or Not to Bind: APP Phosphorylation and Fe65
With the growing realization... 30 Jun 2006.
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Pimplikar S. on LIVE DISCUSSION: Gain or Loss of Function—Time to Shake up Assumptions on γ-Secretase in Alzheimer Disease?, From this debate, it is becoming apparent that the 42:40 ratio hypothesis (increased Ab42/40... 6 Jun 2006.
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Pimplikar S. on NEWS: Paper Alert: Pathology Reversed by Abolishing APP Caspase Site, APP Cytoplasmic Domain: An Orphan No More!
A central tenet of the “amyloid cascade... 24 May 2006.
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Pimplikar S. on NEWS: Aiding and Abetting, Hyperactive CDK5 Gives Mouse Tangles, An interesting observation emanating from the studies of Noble et al. is that the... 27 May 2003.
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1 to 30 of 31 results |
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