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Lee J, Nixon R, Wolfe D. on NEWS: Presenilins and Calcium: A Lysosomal Stew With Acid Controversy, We appreciate the responses of Annaert and colleagues. We believe disagreement centers on the... 13 Sep 2012.
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Lee J, Nixon R, Wolfe D. on NEWS: Presenilins and Calcium: A Lysosomal Stew With Acid Controversy, Controversy makes for better news than consensus but we need to keep in mind that there is... 15 Jul 2012.
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Nixon R. on NEWS: Evidence Piles Up for Lysosomal Dysfunction in Parkinson’s, The lysosomal acidification defect linked to cytotoxicity of mutations in the P-type ATPase... 19 Jun 2012.
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Nixon R. on PAPER: Tian Y. et al., 2011, The findings of Tian and colleagues add to the growing appreciation of autophagy as a pathway... 30 Mar 2011.
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Nixon R. on PAPER: Alvarez-Erviti L. et al., 2010, Given the rapidly accumulating evidence for defective autophagy as an important pathogenic... 23 Dec 2010.
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Cuervo A, Nixon R. on PAPER: Lee JH. et al., 2010, Reply to comment by Tony Wyss-Coray
Since its very early descriptions, autophagy has... 24 Jun 2010.
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Nixon R. on NEWS: Death of the Neatnik: Neurons Perish When Trash Clutters Their Space?, The results in Jaeger et al. reinforce previous work from their lab ( 16 Jun 2010.
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Nixon R. on NEWS: Dual Secretase Approach Shows Promise in AD Mice, The partial inhibition of both secretases is quite interesting, and the results could easily be... 8 Jan 2010.
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Nixon R. on NEWS: Anne Cataldo, 57, Autophagy Researcher Known for Generous Collegiality, “One of the kindest colleagues I ever had” wrote a friend of mine today upon learning of Anne’s... 22 Apr 2009.
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Nixon R. on NEWS: Research Brief: Calpain Inhibitor All Wrapped Up, The relationship between calpain and its endogenous inhibitor protein calpastatin in Alzheimer... 25 Nov 2008.
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Nixon R. on LIVE DISCUSSION: Leon Thal Symposium Webinar, Although preventative and disease-modifying neurological treatments for AD are unquestionably a... 29 Oct 2008.
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Nixon R. on PAPER: Pickford F. et al., 2008, The Pickford et al. study adds strong support to an emerging view that autophagic-lysosomal... 10 Jun 2008.
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Nixon R. on PAPER: Williams A. et al., 2008, The findings reported by the Rubinsztein group on new targets for Huntington disease also have... 9 Apr 2008.
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Nixon R, Yuan A. on PAPER: Yuan A. et al., 2008, Reply by Aidong Yuan and Ralph Nixon to comments
Our study was an in vivo test of... 27 Feb 2008.
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Nixon R. on PAPER: Laifenfeld D. et al., 2007, Studies of Alzheimer disease in Down syndrome (DS) and DS mouse models have shown a close... 24 Jul 2007.
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Nixon R. on NEWS: New Targets for Neurodegenerative Diseases: Autophagy and More, Rapamycin has been a crucial pharmacological tool for positively regulating autophagy through... 11 May 2007.
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Nixon R. on NEWS: Role Reversal—AD Mouse Desperately Seeks CatB, The study by Mueller-Steiner and colleagues firmly establishes cathepsin B as a biologically... 24 Sep 2006.
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Nixon R. on NEWS: Autophagy Prevents Inclusions, Neurodegeneration, The extreme scarcity of autophagic vacuoles in normal brain and their appearance in states of... 24 Apr 2006.
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Nixon R. on NEWS: Dynein—Mutations Put the Brakes on Aggregate Clearance, Rubinsztein and colleagues present strong evidence that macroautophagic turnover of proteins... 6 Jul 2005.
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Nixon R. on NEWS: A New BACE for Immunotherapy, The creative approach reported by Arbel and colleagues to reduce Aβ burden using site-directed... 18 May 2005.
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Nixon R. on NEWS: Varicose Axons: Traffic Jams Precede AD Pathology in Mice, Men, Building on their earlier provocative findings linking APP function to fast axonal transport,... 28 Feb 2005.
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Nixon R. on NEWS: Orlando: It’s Getting Hot around CDK5, Has the Field Noticed Yet?, The pathological cascade proposed in this news story—initiated by calpain activation and p35... 18 Nov 2002.
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Nixon R. on NEWS: The Limits of Compensation: Double Loss of Proteases Causes Massive Neuronal Death, I have to take issue on two accounts with Phil Wong's assessment of the Felbor et al. study. ... 12 Nov 2002.
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Nixon R. on NEWS: In C. Elegans, Aspartyl Proteases and Calpain, Not Caspases, Play the Grim Reaper, In their careful genetic analysis in C. elegans, Syntichaki and colleagues present a... 2 Nov 2002.
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