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Mack J. on NEWS: Pump It Up—Presenilins Linked to ER SERCA Activity, Recommendation Only. 15 Jul 2008.
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Mack J. on NEWS: Paris: Intracellular Traffic and Neurodegenerative Disorders, I find this research compelling. I have always maintained that basic cell/molecular/genetic... 9 Jul 2008.
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Mack J. on NEWS: Deactivation Flaws Predict Memory Troubles, These findings seem consistent with how the neurons of various brain loci communicate. The... 25 Jun 2008.
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Mack J. on SITE POLL: Is AD just the extreme end of the spectrum of normal brain aging?, To be sure, one may age under normal or non-pathological circumstances; however, it should... 1 Apr 2008.
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Mack J. on LIVE DISCUSSION: Presenilin Loss of Function—Plan B for AD?, It would seem reasonable to extrapolate from the current data that loss of appropriate protein... 28 Feb 2007.
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Mack J. on What We Know, What We Don't Know, Aging increases the probability of virtually all common diseases within the demographic the... 28 Feb 2007.
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Mack J. on What We Know, What We Don't Know, Most of the primary literature and latest textbooks reveal that amyloid beta plaques and tangles... 28 Feb 2007.
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Mack J. on LIVE DISCUSSION: Presenilin Loss of Function—Plan B for AD?, I wholeheartedly agree with Ilya Bezprozvanny. Calcium leakage is an important consequence of... 14 Feb 2007.
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Mack J. on SITE POLL: Do PS1 mutations cause AD by cranking up Abeta? Recent findings cast doubt (see Discussion. ) Your reaction?, AB is still primary and largely causative in Alzheimer's disease as well as many other... 11 Oct 2006.
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Mack J. on NEWS: Total Recall—Age, Genetic Variation, and Memory, If G protein-linked glutamate receptors are an important component through neural cell... 14 Mar 2006.
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Mack J. on NEWS: Ataxia—Rare Spectrin Mutations and a Rarer Pedigree, I highly reccomend these primary papers. Finally some truly relevant research in a more direct... 13 Feb 2006.
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Mack J. on NEWS: Mouse of a Different Color: Presenilin Mutations Affect Melanin, I believe this reductionist finding will have important implications for future molecular... 23 Jan 2006.
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Mack J. on NEWS: Tracing Alzheimer Disease Back to Source, It would certainly make sense if the medial temporal lobe is affected early and perhaps most... 12 Sep 2005.
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Mack J. on NEWS: A Homeo Run for the Vascular Hypothesis?, This hypothesis is old and dead. Of course hypoperfusion can increase the risk of AD, but is not... 30 Aug 2005.
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Mack J. on NEWS: Fats, Aβ, Oxidative Stress: Feeding Forward and Backward, Killing Neurons?, Superb paper! I think linking this research with receptor-dependent and -independent pathways... 30 Aug 2005.
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Mack J. on NEWS: Nicastrin—A DAPper Role in γ-Secretase, I find this article very informative, however, it is merely educational. While I find it... 30 Aug 2005.
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Mack J. on NEWS: Stem Cells: New Ways to Make Them Branch Out, I think the new applications utilizing D15A looks very promising, but the nanotechnolgy has more... 11 Aug 2005.
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Mack J. on SITE POLL: What's tau got to do with it?, Tau both plays an integral role in axonal transport cellular reactivation and further... 8 Aug 2005.
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Mack J. on NEWS: Amyloid-β—On or off the Wall?, I believe the bystander effect is heavily implicated here and anyone familiar with comments on... 8 Aug 2005.
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Mack J. on NEWS: Cannabinoid Receptors and AD: Searching Beyond the Simple Story, Pat McGeer makes an interesting point, but further review of the research shows that agonists of... 5 Mar 2005.
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Mack J. on NEWS: Statins and AD—What Role Isoprenoids?, I find this paper encouraging to research in the area of statins and effects on various esters,... 5 Mar 2005.
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Mack J. on NEWS: Varicose Axons: Traffic Jams Precede AD Pathology in Mice, Men, Kinesin molecular motor protein is involved axonal transport along microtubules. Tau protein is... 5 Mar 2005.
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Mack J. on NEWS: Statins and AD—What Role Isoprenoids?, Downregulation of clathrin-mediated intracellular transport; desensitization of... 4 Mar 2005.
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Mack J. on SITE POLL: If a selective COX-2 inhibitor were shown to prevent or slow
down AD, would you take it?, Cycloxygenase inhibitors leave too much to be desired. Side effects include: GI,GU, and liver... 2 Mar 2005.
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Mack J. on NEWS: Cannabinoid Receptors and AD: Searching Beyond the Simple Story, This is probably the best paper on the subject I have seen yet. If CB1 receptors in the brain... 2 Mar 2005.
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Mack J. on SITE POLL: To cure AD, do we need to understand APP and Abeta function?, I agree with this comment. We could analyze APP and Aβ until we are blue in the face, but the... 21 Feb 2005.
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Mack J. on NEWS: There’s Something FISHy About Aβ Toxicity, I think we are getting off track abit. It has been established for some time that various... 21 Feb 2005.
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Mack J. on SITE POLL: Does cerebral amyloid angiopathy (CAA) get enough attention
from AD researchers? Please explain your reply., Many resarchers are dedicated to the correlational study of CAA and some AD patients. Most AD... 21 Feb 2005.
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Mack J. on PAPER: D'Andrea MR. et al., 2005, We should be cautious in how we classify AD. It is heterogenic, with more genes being discovered... 21 Feb 2005.
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Mack J. on PAPER: Monsonego A. et al., 2003, Although it is true that immune response, and the resulting higher levels of selective... 4 Feb 2005.
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1 to 30 of 30 results |
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