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Holtzman D. on NEWS: Does ApoE4 Lower Brain Metabolism Independently of Aβ?, These are intriguing findings.
It is clear from animal and human studies that ApoE4 has a... 14 Dec 2012.
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Holtzman D. on PAPER: Narayan P. et al., 2012, This paper by Narayan et al. beautifully illustrates that purified human clusterin interacts in... 4 Jan 2012.
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Holtzman D. on PAPER: Castellano JM. et al., 2011, I want to thank Lars Nilsson for his comments on our recent paper. I think it is important to... 26 Jul 2011.
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Bero A, Holtzman D. on NEWS: Do Overactive Brain Networks Broadcast Alzheimer’s Pathology?, We would like to reply to comments by Gouras and colleagues regarding our manuscript. Gouras,... 14 May 2011.
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Holtzman D. on PAPER: Schrijvers EM. et al., 2011, I have been interested in clusterin for some time, as it is somewhat similar to ApoE in several... 12 Apr 2011.
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Holtzman D. on PAPER: Reddy MM. et al., 2011, I think this new unbiased technology of looking for IgGs that bind to unique shapes on synthetic... 14 Jan 2011.
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Holtzman D. on PAPER: Storandt M. et al., 2010, Recommendation Only. 13 Nov 2010.
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Holtzman D. on PAPER: Arvanitakis Z. et al., 2010, In the absence of CAA-related hemorrhage, it has been difficult to know how much CAA might... 13 Nov 2010.
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Fagan A, Holtzman D, Morris J. on PAPER: De Meyer G. et al., 2010, Reply to comment by Wes Ashford
Although it is true that ApoE genotype is associated... 23 Sep 2010.
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Holtzman D. on NEWS: What Do Clinicians Say? Peers Welcome Revised Criteria, There is currently no effective treatment for Alzheimer disease. The new proposed diagnostic... 4 Aug 2010.
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Holtzman D, Verghese P. on PAPER: Fitz NF. et al., 2010, A high-fat diet alters cellular metabolic equilibrium and influences the risk of developing... 21 May 2010.
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Holtzman D, Perrin R. on LIVE DISCUSSION: Together at Last, Top Five Biomarkers Model Stages of AD, Dr. Jack and others offer a well-reasoned and clearly explained model in which five of the “most... 20 Jan 2010.
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Holtzman D. on PAPER: van Exel E. et al., 2009, The findings in this paper are interesting. The finding that ApoE4 is much more frequent in... 4 Nov 2009.
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Holtzman D. on PAPER: Caselli RJ. et al., 2009, Caselli and colleagues show that in asymptomatic, clinically normal individuals with a mean age... 21 Jul 2009.
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Holtzman D. on SITE POLL: Are you in favor of ICAD going annual?, I believe the decision of ICAD to occur annually is not in best interest of the field. Having... 17 Nov 2008.
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Holtzman D. on NEWS: AD Immunotherapy: Toward Prevention, DNA-based Vaccines?, I think this very well-performed study shows that in mice, an Aβ vaccination strategy using a... 7 May 2008.
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Holtzman D. on NEWS: Synuclein Surprise: Toxicity Linked to Aβ, Plaques?, This paper by Sudhof and colleagues is quite interesting. The data are convincing that somehow,... 29 Feb 2008.
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Holtzman D. on PAPER: Singleton AB. et al., 2003, This is a key paper in establishing the role of synuclein and synuclein misfolding in Parkinson... 26 Sep 2007.
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Holtzman D. on PAPER: Sadowski MJ. et al., 2006, Sadowski and colleagues examine the effects of a modified Aβ peptide 12-28P that has a proline... 8 Dec 2006.
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Holtzman D, Wahrle S. on NEWS: ABCA1 Loss Lowers ApoE, Not Amyloid; New ApoE Immunology, Comment on the Wahrle et al., Koldamova et al., and Hirsh-Reinshagen et al.... 21 Oct 2005.
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Holtzman D. on PAPER: Marchesi VT. et al., 2005, Vincent Marchesi puts forward a potential alternative mechanism as to how the amyloid-β (Aβ)... 10 Oct 2005.
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Holtzman D. on LIVE DISCUSSION: Messing with the Membrane—An Alternative Interpretation of the Amyloid-β Hypothesis, Vincent Marchesi puts forward a potential alternative mechanism as to how the amyloid-β (Aβ)... 10 Oct 2005.
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Holtzman D. on NEWS: A Homeo Run for the Vascular Hypothesis?, Wu and colleagues, in a recent Nature Medicine paper, report a potential role for the MEOX2... 23 Aug 2005.
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Holtzman D. on PAPER: Du Y. et al., 2005, Du and co-workers examine mechanisms of regulation of the ApoE promoter in a human glial cell... 25 May 2005.
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Holtzman D. on NEWS: Early Intervention Trial Bears Little Fruit, but Sows Hope, Leon Thal and Ron Petersen presented data at the AAN meeting on 4/13/05 that was published today... 15 Apr 2005.
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Holtzman D. on NEWS: Pilot Study Shows Promise of Passive Immunotherapy, Dr. Norman Relkin and colleagues presented data at this year’s American Academy of Neurology... 14 Apr 2005.
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Holtzman D. on NEWS: Varicose Axons: Traffic Jams Precede AD Pathology in Mice, Men, This paper by Stokin et al. from the lab of Larry Goldstein has some interesting and important... 2 Mar 2005.
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Fryer J, Holtzman D. on NEWS: Study Poses Cautionary Question: Will Knocking Down Aβ42 Promote Amyloid Angiopathy?, The exciting data presented in the Herzig et al. paper provide key insights into some of the... 18 Aug 2004.
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Holtzman D. on NEWS: ABCA1 Links Cholesterol and ApoE, But It May Not Be a Risk Factor for AD, ABCA1 has been shown to be critical outside the brain for effluxing phospholipid and cholesterol... 13 Aug 2004.
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Holtzman D. on NEWS: New Marker for AD on the Horizon?, This paper shows that immunostaining for CCR1 is increased in AD brains and tends to increase as... 21 Oct 2003.
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