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1 to 30 of 41 results |
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Chavez-Gutierrez L, De Strooper B, Elad N. on NEWS: First Crystal Structure of a Presenilin, The crystal structure of an archaea homologue of presenilin (mmPSH), just published in Nature,... 20 Dec 2012.
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De Strooper B. on NEWS: CTAD: New Data on Sola, Bapi, Spark Theragnostics Debate, Regarding the question of how presenilin FAD mutations affect Aβ production that is being... 29 Nov 2012.
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De Strooper B, Mandemakers W, Matta S, Verstreken P. on NEWS: New Substrate for Parkinson’s Protein Is Picky About Phosphate, We are grateful for the interest in our paper describing EndoA as a LRRK2 target in synaptic... 16 Oct 2012.
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Benilova I, De Strooper B. on NEWS: Pyromania: PyroGluAβ Toxicity is Prion-Like, Depends on Tau, Nussbaum et al. show that when as little as 5 percent of Aβ is in the pyroglutamylated... 14 Jun 2012.
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Chavez-Gutierrez L, De Strooper B. on PAPER: Zhang X. et al., 2012, We read with great interest the manuscript of Zhang et al. They provide preliminary evidence for... 31 May 2012.
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De Strooper B. on PAPER: Cruchaga C. et al., 2012, Recommendation Only. 13 Feb 2012.
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De Strooper B. on PAPER: Sperling RA. et al., 2011, The scientific evidence in favor of amyloid-β being part of the AD mechanism is, in my opinion,... 14 Dec 2011.
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De Strooper B. on PAPER: Ahn K. et al., 2010, This is a breakthrough in γ-secretase research. The in vitro reconstitution assay allows us to... 23 Dec 2010.
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De Strooper B. on PAPER: Eisele YS. et al., 2010, Recommendation Only. 2 Nov 2010.
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De Strooper B. on NEWS: Research Brief: Did γ-Secretase Mutation Get Under Karl Marx’s Skin?, This work is a strong support for the central role of Aβ peptide in the causation of familial... 7 Oct 2010.
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De Strooper B. on PAPER: He G. et al., 2010, I am very enthusiastic about this paper. The authors identify a 16-kDa protein that apparently... 3 Sep 2010.
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De Strooper B. on NEWS: Lilly Halts IDENTITY Trials as Patients Worsen on Secretase Inhibitor, Obviously, this is a serious disappointment. The negative effects on cognition and on the... 18 Aug 2010.
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De Strooper B. on PAPER: Kuhn PH. et al., 2010, This is a nice and quite systematic study of the long-standing question, What protease is... 13 Aug 2010.
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De Strooper B. on PAPER: Fukumori A. et al., 2010, I recommend this paper. It is very nice work, clever use of molecular biology and mass spec, and... 22 Jun 2010.
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De Strooper B. on PAPER: Yanagida K. et al., 2009, Recommendation Only. 13 Jan 2010.
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De Strooper B. on PAPER: Yan P. et al., 2009, This is excellent work. The authors make elegantly the case that the procedures used to... 2 Sep 2009.
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De Strooper B. on NEWS: Perpetrator and Savior—Presenilins Cut Both Ways, This is a very elegant knockout study reinforcing previous work of Jie Shen published in Neuron,... 11 Jun 2009.
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De Strooper B, Morais V, Scorrano L. on NEWS: That Touch of Pink1—Toning Mitochondrial Respiration, We appreciate the comments of Dr. Pallanck on our work, but would like to add some additional... 7 May 2009.
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De Strooper B. on SITE POLL: Are you in favor of ICAD going annual?, I do not think it is good to put an ICAD meeting so close to the AD/PD meeting. This will split... 19 Nov 2008.
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De Strooper B. on PAPER: Selbach M. et al., 2008, Recommendation Only. 5 Aug 2008.
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De Strooper B. on PAPER: Selbach M. et al., 2008, Selbach et al. and Baek et al. present two nice papers that make an important methodological... 4 Aug 2008.
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De Strooper B, Tolia A. on NEWS: Keystone: γ Slowly Relinquishes Its Secrets, We enjoy reading about the enthusiasm raised by the recent findings by the Iwatsubo group with... 16 May 2008.
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De Strooper B. on PAPER: Meyer-Luehmann M. et al., 2008, Recommendation Only. 25 Feb 2008.
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De Strooper B, Mandemakers W, Morais V. on NEWS: Local Control: Dendritic BC1 RNA Regulates Dopamine Receptor Levels, The Brain Cytoplasmic RNA BC1 Regulates Dopamine D2 Receptor Mediated Transmission in the... 21 Aug 2007.
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De Strooper B. on PAPER: Spasic D. et al., 2007, Recommendation Only. 5 Mar 2007.
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De Strooper B. on PAPER: Shen J. et al., 2007, Very interesting review providing a fair and original account of the available data. I strongly... 9 Jan 2007.
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Chavez-Gutierrez L, De Strooper B, Tolia A. on PAPER: Sato C. et al., 2006, Cysteine scanning as a tool for structure function analysis of presenilin
The new... 20 Nov 2006.
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De Strooper B. on LIVE DISCUSSION: Gain or Loss of Function—Time to Shake up Assumptions on γ-Secretase in Alzheimer Disease?, It was a great idea to have this discussion online. Different views have confronted each other... 24 May 2006.
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De Strooper B. on PAPER: Lazarov VK. et al., 2006, Recommendation Only. 28 Apr 2006.
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De Strooper B. on PAPER: Deng Y. et al., 2006, Recommendation Only. 25 Apr 2006.
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The ALS Forum is a web-based collaborative effort to bring together valuable ALS-related resources for use by researchers worldwide in both academia and industry-based settings.
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Should the FDA be allowed to use data from overseas clinical trials? |
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Absolutely, we are running out of viable subjects in the U.S. |
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 9 |
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Yes, so long as the data is reliable |
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31 |
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No, the trials are not as rigorous |
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3 |
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No, the data should be repeated in the U.S. |
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5 |
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No, the drug sponsors are just trying to cut corners |
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3 |
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Responses: 51 |
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