I recommend this paper
The authors state that “perturbation of the transport of a limited set of proteins has been occasionally reported for other neurodegenerative diseases [than Alzheimer's].”
In fact, we have shown that the anterograde transport of distinct cargos is impaired in our K369I tau transgenic K3 mice and in Alzheimer disease brain.
Ittner LM, Fath T, Ke Y, Bi M, van Eersel J, Li KM, Gunning P, Götz J (2008) Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia, Proc. Natl. Acad. Sci. USA 105: 15997-16002. Abstract
Ittner LM, Ke YD, Götz J (2009) Phosphorylated tau interacts with JNK interacting protein 1 (JIP1) in Alzheimer’s disease, J. Biol. Chem. 284: 20909-16. Abstract
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