Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Lin X, Parisiadou L, Gu XL, Wang L, Shim H, Sun L, Xie C, Long CX, Yang WJ, Ding J, Chen ZZ, Gallant PE, Tao-Cheng JH, Rudow G, Troncoso JC, Liu Z, Li Z, Cai H. Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein. Neuron. 2009 Dec 24;64(6):807-27. PubMed Abstract

	Comments on Paper and Primary News

	Primary News: α-Synuclein Conspires With LRRK2 to Corrupt Neurons Comment by: Bharathi Shrikanth Gadad
	Submitted 6 January 2010 \| Permalink	Posted 13 January 2010
	The paper aims to understand a novel physiological function of LRRK2 by mingling with the mutant α-synuclein protein. The approach seems fascinating. The authors plausibly suggest a link between LRRK2 and AD via the microtubule binding protein tau. However, several mechanisms run in parallel between AD and PD. The question arises whether it is a single disease with multiple kinds of dysfunction or multiple disorders? View all comments by Bharathi Shrikanth Gadad

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