Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Sun B, Halabisky B, Zhou Y, Palop JJ, Yu G, Mucke L, Gan L. Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease. Cell Stem Cell. 2009 Dec 4;5(6):624-33. PubMed Abstract

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REAGENTS/MATERIAL:
Aβ levels in the hippocampus of 3- to 4-week-old and 2- to 3-month-old hAPPJ20 mice were measured by ELISA (Johnson-Wood et al., 1997)
Immunostaining: Coronal brain sections (30 mm) were blocked with blocking buffer and incubated with rabbit anti-GFP (Invitrogen), mouse monoclonal anti-NeuN (A60) (Chemicon), rabbit anti-NPY (ImmunoStar), and mouse monoclonal anti-BrdU (BMC 9318) (Roche), followed by incubation with appropriate secondary antibodies.