Lord A, Gumucio A, Englund H, Sehlin D, Sundquist VS, Söderberg L, Möller C, Gellerfors P, Lannfelt L, Pettersson FE, Nilsson LN. An amyloid-beta protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease. Neurobiol Dis. 2009 Dec;36(3):425-34. PubMed Abstract

REAGENTS/MATERIAL:
Antibodies used in this study:
mouse monoclonal anti-Amyloid-β protofibrils mAb158; mouse monoclonal anti-Amyloid-β protofibrils mAb1C3; mouse monoclonal anti-Aβ1-42 (4G8) (Covance Inc., Denver, PA), and mouse monoclonal anti-Aβ1-16 (6E10) (Covance Inc., Denver, PA); rabbit anti-Aβ40 or anti-Aβ42 specific Aβ antibodies (Näslund et al., 2000); mouse monoclonal anti-N-terminal Aβ (82E1) (IBL-Hamburg, Hamburg, Germany); monoclonal anti-Aβ42 (Signet, Covance Research Products Inc., Denver, PA) and biotinylated monoclonal anti-Artic Aβ mAb27 (0.5 μg/ml), with an epitope in the mid-domain of the Arctic Aβ peptide (Lord et al., 2009).