Nitroglycerin is said to easily cross the blood-brain barrier and enhance cGMP expression (1). Perhaps you'd expect to see a lower incidence of AD in those using the Nitrodur patch.
Of further relevance to AD is the study by Brink and colleagues which reports that sildenafil increases muscarinic acetylcholine receptor signaling in human neuroblastoma cells (2). Is the induction of NOS downstream of mAChR? I refer to my previous post in which I ask whether nitroglycerin (sp) has been used as a NO donor in the treatment of AD (3).
1. Tassorelli C, Blandini F, Greco R, Nappi G. Nitroglycerin enhances cGMP expression in specific neuronal and cerebrovascular structures of the rat brain. J Chem Neuroanat. 2004 Mar;27(1):23-32. Abstract
2. Brink CB, Clapton JD, Eagar BE, Harvey BH. Appearance of antidepressant-like effect by sildenafil in rats after central muscarinic receptor blockade: evidence from behavioural and neuro-receptor studies. J Neural Transm. 2008;115(1):117-25. Abstract
3. Comment by Mary Reid
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