I recommend the Primary Papers
Amber Dance has nicely summarized both papers. Concerning the Cucchiaroni paper, I believe it is a very important contribution to the literature. Deborah Mash, John Pablo, and colleagues have recently confirmed prior studies by Paul Cox and colleagues that BMAA is accumulated in the brains of patients with Alzheimer disease. They also showed that BMAA is accumulated in the brains of patients with amyotrophic lateral sclerosis, but not in brains of control patients or those with Huntington disease. They have obtained preliminary evidence that BMAA is accumulated in the brains of patients with Parkinson disease.
The concentration of BMAA in the protein-bound fraction of the brains of Chamorros with ALS/PDC is of the order of 5 mM, while that in the brains of patients with AD, PD, and ALS is approaching 1 mM. However, Cox and colleagues found that the concentration of BMAA in the soluble fraction of the brains of Chamorros with ALS/PDC was about 50 micromolar.
The paper by Cucchiaroni et al. demonstrates a significant physiological effect of BMAA on dopaminergic neurons. It...